Dr. Leonardo Bear

Let me introduce myself. It's a great pleasure. My name is Dr. Leonardo Bear, and I am an integrative therapist specializing in body and mind health. I own BEAR NUTRITION LABS and am the creator of the "THE BEAR KING" therapeutic method, and the IMMUNOBEAR and IMMUNOGUIDE products.

I will explain the reasons that led me to create this ecosystem.

After the pandemic, many of us faced profound changes in our bodies and minds. My mother was one of them: fatigue, mood swings, circulation problems, aches, and memory lapses became part of her life.

Lethargy set in, her blood pressure rose, her legs swelled, and her circulation weakened. As an integrative therapist, I knew this was a dangerous path. Excess weight, combined with lack of movement and fragile vascular health, was turning her body into fertile ground for new problems.

Faced with this challenge, I realized I couldn’t wait for science to deliver a definitive solution. With my background in integrative therapy and deep knowledge of nutrition, I understood that supplements were the only viable alternative—though they don’t cure, prevent, or treat diseases, their benefits are undeniable. My mother needed something beyond what was already on the market. The multivitamins available to support the immune system no longer met the new needs of a population that had endured a pandemic. The world had changed—and our care needed to change too. Caring for her health became my personal mission.

That's how IMMUNOBEAR and IMMUNOGUIDE were born ✨

They are not just another generic product: they were created to meet the new needs that arose after the pandemic.

My mother. My mark. My legacy

You’ve invested too much in your health to let this chance slip away.

Leaving this page means giving up on a package of exclusive strategies and bonuses, valued at over $1,000, Designed to support your wellness and health process.

Why risk missing this chance?

Why spend significantly more on corrective treatments?

Realizing my mother’s suffering and her new needs, I created an immune-boosting multivitamin that went far beyond the traditional formulas available on the market. Isolated vitamins were no longer enough. She needed something more robust, capable of acting on multiple fronts of her health.

The original and complete formula has been kept secret for security and exclusivity reasons until its official release by the sales department and regulatory bodies. However, its key areas of application can already be highlighted:

✅ Exclusive Benefits of IMMUNOBEAR®

• Antioxidants and anti-inflammatories: Combat free radicals and reduce chronic inflammation.

• Metabolism activation: Stimulates energy and vitality in daily life.

• Mitochondrial biogenesis: Promotes the production of new mitochondria, increasing cellular energy efficiency.

• Neuroprotection:It helps protect neurons and improve memory and concentration.

• Immunomodulation: It helps to balance and strengthen the immune system.

• Autophagy induction: Promotes cell renewal and longevity.

• Increased glutathione: Enhances the body's main natural antioxidant.

• Vasodilation and nitric oxide modulation: Improves circulation and vascular health.

• Fibrinolytic action: Helps reduce the risk of blood clots and promotes cardiovascular well-being.

Now I will explain what IMMUNOBEAR is, and why it is so effective and different from others.

I wondered: why are there so many well-developed products and methods, but the results aren't truly effective or lasting?

Seeking answers, I delved into various scientific studies and realized the obvious: the body and mind need to be prepared to receive any treatment or supplement. Just as a farmer prepares the soil before planting, we also need to prepare our inner terrain so that the results are more consistent and transformative.

It was from this reflection that IMMUNOGUIDE was born — the union between scientific knowledge and my exclusive training, THE BEAR KING Method, which integrates psychological, physical, and nutritional aspects.

IMMUNOGUIDE offers modern techniques and strategies to strengthen health and vitality, preparing the body so that supplements, medications, or treatments act more effectively and lastingly.

I'll explain how I created IMMUNOGUIDE.

By combining these two products, I realized I had discovered something extraordinary. I named this concept "Rebuilding the Human Ecosystem."

What emerged was much more than a formula: I created an effective health, wellness, and mental balance program for my mother—elderly, obese, and with reduced mobility. That alone would be remarkable, considering her unfavorable conditions.

But there was more: a product capable of helping restore her quality of life, vitality, and meet her body's real needs. It was the best of both worlds:

Therefore, for any wellness strategy to be truly effective, the body and mind need to be in optimal condition. IMMUNOBEAR is a powerful supplement, but to fully benefit from it, it should be combined with IMMUNOGUIDE: a psychological and physical preparation protocol developed to restore internal balance and increase the body's responsiveness. A balanced body amplifies the impact of any wellness approach.

Together, they form a complete system:

• IMMUNOGUIDE prepares the ground.

• IMMUNOBEAR and activates the system.

This synergy reflects our philosophy at BEAR NUTRITION LABS: wellness is not a quick fix. It's a conscious journey.

"Health doesn't come from medication or supplements; it's born from awareness, preparation, execution, and consistency in preventive and corrective processes. Health is not a finish line, it's a journey, and those who aren't interested in going through that process will compromise their health with medication in an attempt to manage problems." Dr. Leonardo Urso

No supplement, no matter how advanced, can reach its full potential if the body and mind are not prepared.

I'll tell you how we at BEAR think

At BEAR NUTRITION LABS, we don’t follow trends. We follow principles.

Our unwavering commitment

True wellness begins with respect: for the body, for science, and for your intelligence.

Our commitment is non-negotiable: Integrity. Transparency. And evidence-informed formulation.

We don’t promise miracles. We don’t sacrifice quality for convenience.

We build trust by creating complete, synergistic formulas designed not just to work, but to make sense.

More than a product: A philosophy

We don’t fragment nutrients to follow market trends. Instead, we invest in comprehensive solutions that prioritize long-term wellness over short-term results. Our mission is to offer natural, thoughtful strategies for vitality—guided by responsibility, awareness, and deep respect for everyone walking this journey with us.

We are not just a brand. We are a movement for conscious wellness. Our ethics align with the needs of our community and the standards of global regulatory authorities. We serve those who believe that wellness is not a trend—it’s a legacy.

A Movement for conscious well-being

Areas Covered in this Training

Mental health

We apply well-established, science-based techniques to support individuals facing post-pandemic emotional challenges such as occasional stress, low motivation, and mood swings, helping to promote emotional balance, mental clarity, and overall well-being.

Physical conditioning

Our holistic program blends personalized nutrition, targeted supplementation, and restorative practices—designed to support metabolic balance and promote overall vitality. A 360° approach for those seeking to elevate their wellness journey naturally.

Specialized nutrition

Our philosophy honors human bonds as foundational to holistic wellness, fostering meaningful connections while nurturing inner resources for times of solitude. A journey of self-discovery that balances belonging and emotional self-sufficiency.

Social life

IMMUNOGUIDE emphasizes regular physical activity as an essential part of a balanced lifestyle. Our efforts to raise awareness of this practice are designed to encourage progressive and adaptive physical wellness, helping maintain vitality during periods of rest and recovery.

Summary of what you will learn with IMMUNOGUIDE

Promotes emotional balance and mental clarity during challenging times

Inside IMMUNOGUIDE, discover how to navigate emotional challenges that may have emerged or intensified in the wake of the pandemic.

This exclusive training, based on THE BEAR KING method created by Dr. Leonardo Bear, offers access to established psychological strategies along with innovative approaches that promote mental, emotional, and behavioral balance—in a practical, accessible, and evidence-based way.

How physical activity can strengthen your body and mind

Inside IMMUNOGUIDE, discover the importance of incorporating physical activity in a practical and safe way to help support energy, resilience, and emotional balance.

Learn why regular movement is considered a key pillar of post-pandemic recovery—and how to adapt it to your lifestyle, even with limited time.

You will learn how to:

• Support safe and natural detoxification processes in the body

• Encourage a more balanced and alkaline internal environment

• Foster gut microbiome harmony to promote digestive comfort and emotional resilience

• Understand the vital role of hydration in cellular renewal

• Integrate functional nutrition and targeted supplementation for sustained wellness

Transformative nutrition: The core of conscious health

At BEAR NUTRITION LABS, we believe that health isn't a product. It's a conscious journey, made up of choices, preparation, and connection. IMMUNOGUIDE is the first step on that journey.

Exclusivity

Advance Preparation

In our quest to amplify the results of IMMUNOBEAR, we made a fundamental discovery: for an advanced formula to deliver its full potential, the body must be receptive.

It's the farmer's logic: the soil must be prepared before the seed is planted.

We understood that the first step wasn't just about nourishment, but about preparing the "human ecosystem"—harmonizing mind, body, and nutrition so that wellness can flourish.

In a world obsessed with volume, we choose value.

While many companies compete for numbers—more sales, more customers, more scale—BEAR NUTRITION LABS ushers in a new era: that of premium and exclusive supplements, developed to deliver real improvements and a transformative shopping experience.

This approach reflects our commitment to quality, exclusivity, and effectiveness. We offer our products to those who seek not just to consume, but to participate in something bigger, more meaningful, and exclusive.

Exclusive advantages of IMMUNOGUIDE, until the arrival of the IMMUNOBEAR

Exclusive bonus for the first 10,000 customers

Exclusive access

Exclusive Access: Be one of the first 10,000 privileged members to get the training and secure your life-changing preferred purchase bonus!

Priority

Guaranteed Priority: You will have exclusive priority access to purchase the first bottles of the product, long before they become available to the general public.

Special Discount: As a thank you for your prompt response, you'll receive an exclusive 20% discount on the IMMUNOBEAR product when it becomes available. This is a unique and unmissable opportunity!

Benefits

To ensure that IMMUNOBEAR® meets the highest safety and efficacy standards, we are diligently following the rigorous regulatory process of the FDA in the United States, where it will begin to be sold. Our projected launch date is April 2026.

For intellectual property protection reasons, the complete and exclusive formula will only be disclosed at the time of the official launch.

How to Secure Your Exclusive Access:

The initial launch of IMMUNOBEAR® will be a limited production run, offered exclusively to founding members of our community — those who purchased the IMMUNOGUIDE® program.

Only after our founding members have had the opportunity to exercise their priority purchase will IMMUNOBEAR® be made available to the general public, if there is any remaining stock.

We greatly appreciate your patience and support. This meticulous process reflects our unwavering commitment to quality and delivering a product you can fully trust.

We emphasize that the launch will follow a strict exclusivity protocol, out of respect for those who secured their place on the waiting list by purchasing the training:

To clarify, the IMMUNOBEAR product will initially be available exclusively to the first 10,000 North American participants who invested in the pre-launch through the IMMUNOGUIDE training.

Those who begin their IMMUNOGUIDE journey will receive a head start—with priority access, a discount, and a body better prepared to receive the best product.

These priority clients will have early and guaranteed access to purchase the product as soon as it becomes available. Only after this stage will IMMUNOBEAR be made available to the general public.

Important note:

Due to the innovation, product quality, and the great need of the world's population regarding this topic, we anticipate unprecedented demand for IMMUNOBEAR. Should demand exceed our production capacity, we will not be able to guarantee availability for everyone. In this scenario, priority access to purchase future batches will be granted only to customers automatically registered by IMMUNOGUIDE, and new slots for exclusive purchase will be opened as our capacity allows.

BENEFIT #1 - Complete IMMUNOGUIDE system: (PDF format, therefore it is recommended to view them on a computer for easier reading) Full access to our health preparation program, based on the essential principles of the exclusive THE BEAR KING™ method (IMMUNOGUIDE price: US$ 87).

BENEFIT #2 - Psychological Support Videos. The psychological content will be available on the platform through subtitled videos (therefore, it is recommended to watch them on a computer to facilitate reading) presented by me, Dr. Leonardo Bear, using my exclusive method THE BEAR KING. There will be approximately 4 sessions, with each session costing US$ 200 (saving US$ 800).

BENEFIT #3 - Priority Access to IMMUNOBEAR Purchase. Your guaranteed pass to be among the first in the world to purchase IMMUNOBEAR. If initial demand exceeds our production capacity, only IMMUNOGUIDE members will be able to purchase. (Price: Priceless / Members Only).

BENEFIT #4 - Exclusive Launch Discount. A guaranteed 20% discount coupon to be used on your first IMMUNOBEAR order (savings of approximately US$18).

BENEFIT #5 - A closed and exclusive community on the platform, valid for one year, to ask questions about the training and access new classes on psychological and physical health topics, taught by me, as well as topics proposed by the community. (Price: R$30 per month, total cost: R$360.)

These are just a few of the benefits. But don't rush, I still have a surprise for you:

IMMUNOGUIDE

That's over $1000 in financial benefits, and as if that weren't enough, you also receive priceless priority and exclusive benefits.

Think for a moment: how much is all this really worth to you? What is the price of your health?

How Your Access Works:

STEP 1: Secure your spot ✔️ Complete your secure purchase of the IMMUNOGUIDE and claim your spot on the pioneer list.

STEP 2: Instant access to the guide ✔️ Within minutes, you'll receive an email with your personal and instant access to the IMMUNOGUIDE training. You can start preparing your body today!

STEP 3: Await the exclusive launch ✔️ Relax and enjoy the guide's content. We'll take care of the rest.

📩 About your priority purchase of IMMUNOBEAR:

As soon as IMMUNOBEAR launches (scheduled for April  2026), you'll be the first to know. We'll send you an email or WhatsApp message with your unique, personal link to order before anyone else.

🔒 100% Digital & Secure | Start Your Training Right Now!

Risk-free trial

You will have 15 full days to test and explore our product with no commitment.

⚠️ Please Note: By requesting a refund, you automatically waive your right to the exclusive early purchase bonus, which is only offered to those who keep their registration active.

Total security

A one-time investment with a full money-back guarantee. Your satisfaction is our priority—if the content doesn't add value to your life, we will refund your money.

⚠️ Please Note: By requesting a refund, you automatically waive your right to the exclusive early purchase bonus, which is only offered to those who keep their registration active.

Our 15-day guarantee is unconditional: access the content, and if it doesn't fully meet your expectations, request a refund simply and quickly.

⚠️ Please Note: By requesting a refund, you automatically waive your right to the exclusive early purchase bonus, which is only offered to those who keep their registration active.

Full warranty

15 day guarantee

IMMUNOGUIDE

Now you decide how much your life is worth?

Remember, this is over $1,000 worth of exclusive benefits. Normally, just one consultation with me costs $200 — and that only includes the session plus the e-book. But because I truly want to make this opportunity available to everyone, and it’s only for a limited time, you can get it all today for just $187!

✅ Full access to IMMUNOGUIDE

🎥 exclusive psychological support sessions

🛍️ Priority access to IMMUNOBEAR purchases

💸 Exclusive 20% discount

🔒 Closed community for 1 year

🔁 15-day guarantee

📝 In a world that is increasingly automated, Bear chooses to go against the grain. We still believe in the value of human relationships and want to preserve the essence of personalized care.

Even with high demand, I remain committed to personally answering my patients’ questions, without automating or outsourcing this service. To expand support, I will provide exclusive content in the members’ area and on our official YouTube channel. There, you can submit your questions — which may be the same as many others — and help create answers that benefit a wider audience.

It's clear that I can't respond to everyone individually, but I reaffirm my commitment to offering the best possible content, with relevant and high-quality information. For practical reasons, my responses will be directed to members of the official YouTube channel and Bear Club members who participate in IMMUNOGUIDE.

Thank you for your understanding and trust, and I remain dedicated to delivering real value to our community.

🙏 Thank you for your understanding and trust.

Dr. Leonardo Bear

YouTube channel: @leonardobearofficial

Email: bearcontact@immunobear.com

About support

We are a young and innovative company that begins its journey modestly, but guided by big dreams and a commitment to truth and the well-being of our clients. We don't offer illusions or exploit weaknesses; our purpose is to build genuine relationships, based on transparency and responsibility.

Many companies have no face, no identity. Here it's different: I am the face of this company. Read my story, get to know who is behind each product. In a digital world dominated by artificial intelligence and robots, I still believe that truth and personal relationships are the greatest virtues between two people.

Of course I want to sell my products, but more than that, as a therapist, I want to connect and create the largest health movement in the world. I know I won't be able to do it alone: ​​I will only achieve this goal with God's grace, your trust, and your help.

— Dr. Leonardo Bear

BEAR NUTRITION LABS

Respect and transparency above all.

Absolutely delighted with my purchase! Excellent product, great knowledge and overall a great shopping experience.

Ronaide - Psychologist 40 years old

My wife bought it for me, I don't have the patience to study, but I'm following what she learned in the course and the results are great, I feel much better.

Renato - Concierge agent 45 years old

★★★★★

★★★★★

Of course, I couldn't help but share the most personal reason behind the creation of IMMUNOBEAR: my mother.

I won't publish her testimonial — after all, like any good mother, she would only have praise. But what I can say with complete honesty is that, after applying the IMMUNOGUIDE techniques and starting to use our health protocol with IMMUNOBEAR, her health has improved considerably, especially in aspects related to vitality, disposition and general well-being.

Creusa - retired 82 years old

★★★★★

Frequently Asked Questions (FAQ)

Question 1: "Does this guide replace a medical consultation?"

Answer: "No. This is a very important question. The IMMUNOGUIDE is a powerful educational tool to support you on your wellness journey, but it does not replace the advice, diagnosis, or treatment from a qualified healthcare professional. We encourage you to always consult your doctor for any health-related matters."

Question 2: "How do I get access to the guide and the bonuses?"

Answer: "The process is simple and fast. After your secure purchase, you will receive an email within 5 minutes with your personal access link to the IMMUNOGUIDE and instructions on how to join our private community. Your name will also be automatically added to the priority purchase list for IMMUNOBEAR."

Question 3: "What if I don't like the guide? How does the guarantee work?"

Answer: "Your satisfaction is our priority. You have 15 full days to explore all the material. If, for any reason, you feel it wasn't worth it, just send us an email, and we will refund 100% of your investment, no questions asked. The only thing to note is that requesting a refund will automatically cancel your spot on the priority purchase list."

Question 4: "Am I obligated to buy IMMUNOBEAR in the future?"

Answer: "Of course not. Purchasing the IMMUNOGUIDE gives you the right and the priority to buy, but not the obligation. You will have the exclusive opportunity to purchase IMMUNOBEAR before anyone else and with a discount, but the final decision will always be yours."

Question 5: "Why should I buy the guide now instead of waiting?"

Answer: "That's a great question, and the answer is about strategy and opportunity. There are two crucial reasons to secure your guide today:

To Enhance Your Results (The Strategy): Using the farmer analogy, the IMMUNOGUIDE is the process of 'preparing the soil.' It teaches your body to be in the ideal state to receive the nutrients and compounds from IMMUNOBEAR. Starting this preparation now means that when you take the product, your body will be ready to absorb and utilize every component much more effectively. It's the difference between planting in fertile soil versus unprepared ground.

To Guarantee Your Access (The Opportunity): The truth is, producing IMMUNOBEAR is a complex and expensive process, and our initial stock will be limited. Due to the enormous demand we are already seeing, it is almost certain that the first batch will sell out in days, or perhaps even hours. Buying the IMMUNOGUIDE now isn't just buying a course; it's buying your only guarantee that you will have a spot at the front of the line. Without it, you will likely have to wait months for a future batch."

Question 6: "What exactly is THE BEAR KING™ method mentioned in the guide?"

Answer: THE BEAR KING™ is an innovative method focused on mental, emotional, and physical resilience, designed to holistically restructure the human ecosystem. Unlike conventional treatments that often overlook the physical and nutritional aspects, this method was developed over years of my clinical practice as a therapist. It goes beyond "positive thinking" by building robust inner strength through pillars such as nutrition, supplementation, and physical activity. With practical techniques, you will learn to control stress, regulate the nervous system, transform anxiety into focus, and rebalance your overall well-being. In the IMMUNOGUIDE, I have adapted these essential principles to help guide you in developing the knowledge needed for a complete physical recovery.

Question 7: " I'm not experiencing any post-pandemic symptoms. Is this guide still useful for me?"

Answer: "Absolutely. Although this product is targeted at a specific audience, IMMUNOGUIDE is a comprehensive training program on overall health. It teaches the necessary journey to achieve vitality and longevity in a world where medicine is expensive and prevention proves to be the smartest choice.

We all need health—and we all have someone in our families who faces these conditions. IMMUNOGUIDE was created to prepare the body and mind, making any supplement, treatment, or medication more effective, while promoting physical, mental, and nutritional balance."

Question 8: "What happens after I buy the guide? Will I get marketing emails forever?"

Answer: "We respect your inbox. After your purchase, you will receive your access details and important emails regarding the IMMUNOBEAR launch. You will also be part of our occasional newsletter with valuable health tips. You can unsubscribe from the newsletter at any time with a single click, and it will not affect your access to the guide or your spot on the priority list."

Question 9: "When will the BEAR Human Development Foundation begin its activities?"

Answer:The foundation does not have a set timeline to begin its work. It is an ambitious and long-term project, and we will be opening opportunities for investors and donors in the near future. However, initial online activities are projected to start in 2026.

Bibliographic References

[Management of patients with lymphatic diseases and lipoedema during the COVID-19 pandemic. Recommendations of the Spanish Group of Lymphology]

https://pubmed.ncbi.nlm.nih.gov/32863012/

• PMID: 32863012

• PMCID: PMC7414319

• DOI: 10.1016/j.rh.2020.07.003

Pathophysiological mechanisms of thrombosis in acute and long COVID-19

https://pmc.ncbi.nlm.nih.gov/articles/PMC9709252/

PMCID: PMC9709252 PMID: 36466841

https://pmc.ncbi.nlm.nih.gov/articles/PMC11465292/

Recent Updates on COVID-19 Associated Strokes

https://pmc.ncbi.nlm.nih.gov/articles/PMC11465292/

PMCID: PMC11465292 PMID: 39391859

Relationship between Hyperlipidemia, Cardiovascular Disease and Stroke: A Systematic Review

https://pmc.ncbi.nlm.nih.gov/articles/PMC8950504/

PMCID: PMC8950504 PMID: 33305711

COVID-19 and Cardiovascular Disease: A Comprehensive Review

https://pubmed.ncbi.nlm.nih.gov/35704865/

PMID: 35704865

COVID’s Damage Lingers in the Heart

https://magazine.hms.harvard.edu/articles/covids-damage-lingers-heart

Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2

https://pmc.ncbi.nlm.nih.gov/articles/PMC9458005/

PMCID: PMC9458005 PMID: 36080170

The Long-Term Cardiovascular Impact of COVID-19: Pathophysiology, Clinical Manifestations, and Management

PMCID: PMC11384648 PMID: 39258051

2024 Aug 10;16(8):e66554. doi:10.7759/cureus.66554

The Long-Term Cardiovascular Impact of COVID-19: Pathophysiology, Clinical Manifestations, and Management - PMC

URL:https://pmc.ncbi.nlm.nih.gov/articles/PMC11384648/

https://www.sciencedirect.com/science/article/pii/S2352906724001489

I. References on Resistin and Metabolic Risk

These references support the idea that resistin is a harmful hormone linked to insulin resistance and health risks.

Resistin as a risk factor for all-cause (and cardiovascular) death in the general population

• URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC9666658/

• Relevance: Confirms that resistin is a risk factor for overall and cardiovascular mortality, reinforcing its role as a "villain".

The Role of Resistin in Macrovascular and Microvascular Complications of Type 2 Diabetes

• URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC12028410/

• Relevance: Associates resistin with the development and progression of type 2 diabetes complications.

Leptin, resistin, and visfatin: the missing link between endocrine metabolic disorders and immunity

• URL: https://eurjmedres.biomedcentral.com/articles/10.1186/2047-783X-18-12

• Relevance: Confirms resistin as an adipokine linked to metabolic disorders and insulin resistance.

II. References on Mitochondrial Dysfunction and Obesity (Including Harvard)

These references support the idea that obesity causes mitochondrial dysfunction, the body's "broken engine."

Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes

• URL: https://hsph.harvard.edu/news/newly-discovered-mechanism-of-mitochondrial-dysfunction-in-obesity-may-drive-insulin-resistance-and-type-2-diabetes/

• Relevance: Study from the Harvard T.H. Chan School of Public Health that identifies a mechanism of mitochondrial dysfunction (excessive ROS production) in obesity, providing Harvard's authority for its narrative.

Mitochondrial Health Markers and Obesity-Related Health in Human Population Studies: A Narrative Review of Recent Literature

• URL: https://pubmed.ncbi.nlm.nih.gov/39287712/

• Relevance: Review summarizing the evidence that altered mitochondrial functions contribute to obesity.

Research | The Sinclair Lab (Harvard Medical School)

• URL: https://sinclair.hms.harvard.edu/research

• Relevance: Demonstrates that Harvard Medical School actively researches mitochondrial function and its relationship to diseases such as Type 2 Diabetes, reinforcing the credibility of its narrative.

III. References on the Unique Mechanism (Resistin vs. Mitochondria)

These references are the most important, as they establish the direct relationship between Resistin and mitochondrial dysfunction, its "unique mechanism".

Resistin destroys mitochondrial biogenesis by inhibiting the PGC-1α/NRF1/TFAM signaling pathway

URL: https://www.sciencedirect.com/science/article/pii/S0006291X18317017

Relevance: Evidence that resistin reduces the number of mitochondria (mitochondrial biogenesis) by inhibiting the "master builder" (PGC-1α).

Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases

URL: https://www.sciencedirect.com/science/article/pii/S0026049522002219

Relevance: Evidence that resistin breaks down and fragments mitochondria (abnormal fission), making them dysfunctional.

IV. Additional Reference (Context)

Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women

URL: https://pubmed.ncbi.nlm.nih.gov/27367031/

Newly detected diabetes during the COVID-19 pandemic: what have we learnt?

Newly detected diabetes during the COVID-19 pandemic: what have we learnt? - PMC

10.1016/j.beem.2023.101793

PMCID: PMC10303323 PMID: 37468405

The enduring effect of the COVID-19 pandemic on diabetes

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00180-3/fulltext

A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on

https://pmc.ncbi.nlm.nih.gov/articles/PMC9107388/

10.1016/j.metabol.2022.155217

PMCID: PMC9107388 PMID: 35584732